Research Article
Evaluation of Adverse Effects of Mutein Forms of Recombinant Human Interferon Alpha-2b in Female Swiss Webster Mice
Table 3
Organ indices of female mice after subcutaneous administration of wild type rIFN-α2b or rIFN-α2bC2DC99D once every 3 days during a 45-day period.
| Organ | Control | Groups | Wild type rIFN-α2b (D4) | rIFN-α2bC2DC99D (D4) | Wild type rIFN-α2b (D5) | rIFN-α2bC2DC99D (D5) |
| Heart | 0.43 ± 0.03 | 0.41 ± 0.013 | 0.41 ± 0.04 | 0.43 ± 0.03 | 0.41 ± 0.03 | Liver | 5.81 ± 0.39 | 5.95 ± 0.33 | 6.14 ± 1.06 | 5.97 ± 0.55 | 5.39 ± 0.26 | Kidney | 1.37 ± 0.16 | 1.39 ± 0.16 | 1.48 ± 0.07 | 1.34 ± 0.05 | 1.30 ± 0.12 | Limp | 0.66 ± 0.15 | 0.59 ± 0.14 | 0.72 ± 0.18 | 0.58 ± 0.14 | 0.48 ± 0.09 | Ovary-uterus | 0.69 ± 0.16 | 0.64 ± 0.12 | 0.78 ± 0.14 | 0.72 ± 0.19 | 0.69 ± 0.19 | Lung | 0.59 ± 0.07 | 0.58 ± 0.02 | 0.60 ± 0.09 | 0.61 ± 0.05 | 0.59 ± 0.07 |
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D4 = 1.95 g/kg BW, D5 = 19.5 g/kg BW.
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