Evaluation of Adverse Effects of Mutein Forms of Recombinant Human Interferon Alpha-2b in Female Swiss Webster Mice

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr class="thead"><td align="left"> </td><td align="center">Control</td><td align="center">Wild type rIFN-<i>α</i>2b (D4)</td><td align="center">rIFN-<i>α</i>2bC<sub>2</sub>DC<sub>99</sub>D (D4)</td><td align="center">Wild type rIFN-<i>α</i>2b (D5)</td><td align="center">rIFN-<i>α</i>2bC<sub>2</sub>DC<sub>99</sub>D (D5)</td></tr><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr><td align="left">SGPT</td><td align="center">54 ± 2</td><td align="center">50.67 ± 14.04</td><td align="center">54 ± 1</td><td align="center">50.33 ± 16.01</td><td align="center">53.33 ± 22.36</td></tr><tr><td align="left">SGOT</td><td align="center">215.67 ± 24.58</td><td align="center">231 ± 19.52</td><td align="center">219.67 ± 44.76</td><td align="center">215.67 ± 41.88</td><td align="center">205 ± 44.03</td></tr><tr class="table-tr"><td colspan="6"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Enzyme activities in plasma of the mice after injection of the interferons once every 3 days during a 45-day period.

BioMed Research International

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Table 4

Table 4: Evaluation of Adverse Effects of Mutein Forms of Recombinant Human Interferon Alpha-2b in Female Swiss Webster Mice 