The Conyza triloba Extracts with High Chlorophyll Content and Free Radical Scavenging Activity Had Anticancer Activity in Cell Lines
Table 8
(a) The 50% growth inhibition (GI50) data of different Conyza extracts in 6 cell lines. (b) The total growth inhibition (TGI) data of different Conyza extracts in 6 cell lines. (c) The 50% lethality (LC50) data of different Conyza extracts in 6 cell lines.
(a)
Extract
Potency of extracts (μg) in cell lines (mean ± SEM); n = 3
HT29
A549
PC3
MCF7
Hepa1C1C7
H4IIE1
I
0.93 ± 0.10
4.07 ± 0.31
1.00 ± 0.05
43.77 ± 3.02
0.70 ± 0.04
0.93 ± 0.04
II
0.47 ± 0.05
0.17 ± 0.01
0.60 ± 0.02
28.13 ± 1.87
0.10 ± 0.01
0.07 ± 0.01
III
0.47 ± 0.02
0.27 ± 0.01
0.67 ± 0.03
10.00 ± 0.79
0.07 ± 0.02
0.10 ± 0.01
IV
0.77 ± 0.04
0.43 ± 0.03
0.87 ± 0.05
10.00 ± 0.88
0.07 ± 0.01
0.07 ± 0.02
V
0.77 ± 0.07
48.43 ± 4.00
6.10 ± 0.53
8.43 ± 0.51
1.00 ± 0.07
0.77 ± 0.06
(b)
Extract
Potency of extracts (μg) in cell lines (mean ± SEM); n = 3
HT29
A549
PC3
MCF7
Hepa1C1C7
H4IIE1
I
6.3 ± 0.51
50.0 ± 6.21
7.7 ± 0.44
375.0 ± 29.12 a
6.0 ± 0.41
7.0 ± 0.91
II
1.7 ± 0.01
1.9 ± 0.07
7.0 ± 0.52
281.3 ± 31.04 a
0.7 ± 0.34
0.3 ± 0.02
III
2.0 ± 0.09
1.6 ± 0.02
6.7 ± 0.47
71.7 ± 5.55
0.3 ± 0.22
0.7 ± 0.01
IV
5.7 ± 0.49
3.3 ± 0.02
7.0 ± 0.34
56.3 ± 4.67
0.3 ± 0.24
0.7 ± 0.03
V
5.3 ± 0.61
437.0 ± 41.11a
478.7 ± 39.29 a
46.7 ± 6.00
34.3 ± 4.01
8.0 ± 1.01
(c)
Extract
Potency of extracts (μg) in cell lines (mean ± SEM), n = 3
HT29
A549
PC3
MCF7
Hepa1C1C7
H4IIE1
I
37.3 ± 4.5
845.0 ± 98.4a
64.0 ± 5.9
>1000a
48.7 ± 5.3
56.3 ± 6.1
II
10.0 ± 2.1
21.7 ± 3.4
71.7 ± 6.4
>1000a
3.0 ± 2.4
2.0 ± 0.5
III
19.0 ± 1.8
10.0 ± 1.5
37.7 ± 2.8
375.0 ± 40.1a
2.3 ± 1.6
2.0 ± 0.4
IV
31.3 ± 2.5
91.0 ± 8.7
18.7 ± 3.3
193.7 ± 21.9
1.7 ± 0.7
4.0 ± 0.3
V
25.7 ± 2.7
>1000a
>1000a
100.0 ± 11.1
130.0 ± 9.9a
65.7 ± 8.0
Extrapolated from dose-response curve. HT29 (human colon), A549 (human lung), PC3 (human prostate), MCF7 (human breast), Hepa1C1C7 (murine liver), and H4IIE1 (rat liver). GI50 is the concentration of an extract (μg) that causes 50% growth inhibition. TGI is the concentration of an extract (μg) that yields no net growth over the course of the assay. LC50 is the concentration of an extract (μg) that kills 50% of the cells that were present at the time of the addition of the extract.
