Review Article
Hemizona Assay and Sperm Penetration Assay in the Prediction of IVF Outcome: A Systematic Review
Table 3
HZA and IVF outcome and summary of diagnostic accuracy findings.
| | Study group, date | HZI threshold (%) | Fertilization rate cutoff (%) | Sensitivity | Specificity | PPV | NPV |
| | Oehninger et al., 1989 [37] | >36 | >65 | 83% | 95% | 83% | 95% | | Oehninger et al., 1991 [38] | >36 | >65 | 80% | 100% | 100% | 85% | | Oehninger et al., 1992 [39] | >35 | >65 | 100% | 61% | 79% | 100% | | | | >0 | 90% | 57% | 82% | 73% | |
Franken et al., 1993 [40]
| >30 | >50 | 84% | 72% | 85% | 70% | |
Franken et al., 1993 [41] | >30 | >55 | 75% | 75% | 81% | 68% | | Gamzu et al., 1994 [42] | >23 | >66 | 100% | 94% | 85% | 100% | | Oehninger et al., 1997 [43] | >30 | >60 | 93% | 73% | 85% | 87% |
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Abbreviations: HZI (hemizona index), PPV (positive predictive value), and NPV (negative predictive value).
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