Emerging Metabolic Targets in the Therapy of Hematological Malignancies

Table 1

Summary of reported alterations in proteins involved in metabolism in different types of cancer.

Protein	Alteration	Tumor type	Reference
GLUT1	mRNA overexpression	Endometrial and breast cancer	[19, 125]
HKII	mRNA overexpression	Glioblastoma multiforme	[126]
PGI	mRNA overexpression	Colorectal cancer	[31]
PFK1	mRNA overexpression	Breast cancer	[34–36]
GAPDH	mRNA overexpression	Lung, renal, breast, colorectal, hepatocellular, and pancreatic cancers	[127–129]
PKM2	mRNA overexpression	Lung, renal, breast, colorectal, and gastrointestinal cancers	[129–133]
LDH-A	Gene amplification	Lung, pancreatic, and colorectal cancers	[92]

GLUT1: glucose transport 1; HK: hexokinase; PGI: phosphoglucose isomerase; PFK: phosphofructokinase; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; PKM2: pyruvate kinase M2; LDH-A: lactate dehydrogenase A.
Information was retrieved from http://www.ncbi.nlm.nih.gov/pubmed.