Table 1: Summary of reported alterations in proteins involved in metabolism in different types of cancer.

ProteinAlterationTumor typeReference

GLUT1mRNA overexpressionEndometrial and breast cancer[19, 125]
HKIImRNA overexpressionGlioblastoma multiforme[126]
PGImRNA overexpressionColorectal cancer[31]
PFK1mRNA overexpressionBreast cancer[3436]
GAPDHmRNA overexpressionLung, renal, breast, colorectal, hepatocellular, and pancreatic cancers[127129]
PKM2mRNA overexpressionLung, renal, breast, colorectal, and gastrointestinal cancers[129133]
LDH-AGene amplificationLung, pancreatic, and colorectal cancers[92]

GLUT1: glucose transport 1; HK: hexokinase; PGI: phosphoglucose isomerase; PFK: phosphofructokinase; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; PKM2: pyruvate kinase M2; LDH-A: lactate dehydrogenase A.
Information was retrieved from