Regulation of Tight Junctions in Upper Airway Epithelium

Table 1

Changes of tight junction proteins and barrier function in HNECs in vitro.

Treatments		Tight junction proteins	Barrier function
FBS		CLDN-1↑; CLDN-4↑	Upregulation
Growth factor	TGF-𝛽	CLDN-4↑	No change
PKC activator	TPA	CLDN-1↑; OCDN↑; ZO-1↑; ZO-2↑	Upregulation
PPAR𝛾 ligands	Rosiglitazone; Troglitazone	CLDN-1↑; CLDN-4↑; OCDN↑; TRIC↑; CLDN-1↑; CLDN-4↑; OCDN↑	Upregulation
TLR3 ligand	Poly I:C	JAM-A↓	No change
Cytokine	TSLP	CLDN-1↑; CLDN-4↑; CLDN-7↑; OCDN↑	Upregulation
Virus	RSV	CLDN-4↑; OCDN↑	Upregulation