Hypoglycemic and Hypolipidemic Potential of a High Fiber Diet in Healthy versus Diabetic Rabbits

Table 1

Pharmacokinetic parameters for glucose obtained on days 14 (healthy rabbits) and 28 (diabetic rabbits) after the administration of an oral 3 g glucose load.

	Day 14 (healthy rabbits)
	Standard chow		Supplemented chow		Standard/supplemented variation
	𝐗  ± SE	CV (%)	𝐗  ± SE	CV (%)
𝑡max (min)	30.00 ± 3.55	36.12	30.00 ± 3.02	35.00
𝐶max (mg/dL)	186.1 ± 5.43	12.37	189.7 ± 9.66	20.60	↑ 3.6%
AUC (mg ⋅ min/dL)	28168.2 ± 689.1	10.63	29539.0 ± 1122.1	16.82	↑ 4.9%
	Day 28 (mild diabetic rabbits)
	Standard chow		Supplemented chow		Standard/supplemented variation
	𝐗  ± SE	CV (%)	𝐗  ± SE	CV (%)
𝑡max (min)	95.00 ± 11.65	34.68	81.67 ± 10.19	39.46
𝐶max (mg/dL)	456.2 ± 26.31^1	15.80	357.1 ± 23.70	27.38	↓ 21.7%
AUC (mg ⋅ min/dL)	73304.3 ± 4939.9^1	18.86	54008.6 ± 3889.8	16.82	↓ 26.3%
	Day 28 (severe diabetic rabbits)
	Standard chow		Supplemented chow		Standard/supplemented variation
	𝐗  ± SE	CV (%)	𝐗  ± SE	CV (%)
𝑡max (min)	118.2 ± 13.24	34.68	97.25 ± 12.87	39.46
𝐶max (mg/dL)	583.8 ± 32.43	15.80	527.7 ± 31.70	27.38	↓ 9.6%
AUC (mg ⋅ min/dL)	98530.0 ± 6556.6	18.86	87486.5 ± 6229.9	27.81	↓ 11.2%

 ¹Significative differences (𝑡-test, P ≤ 0.05).