Nanocarriers for Diagnosis and Targeting of Breast Cancer

Table 1

Types of nanocarriers for drug delivery.

Sr.; no.	System	Structure	Characteristics	Example of; compounds	References
1	Polymeric micelles	Hydrophobic core and hydrophilic shell are formed by assembling amphiphilic block copolymer	(a) Efficient carrier system for hydrophilic drug; (b) Biodegradable, self-assembling, and biocompatible; (c) Potential targeting; (d) Functional modification	PEG-b-p(LA-CO-MCG); PEG-B-PCL; Curcumin micelles	[1–3]
2	Dendrimers	Synthetic polymer forming nanosized branched structure with repeated units and regular pattern	(a) Uniformity in size, shape, and branch length; (b) Tuned pharmacokinetics and biodistribution; (c) Increased surface area, increased loading; (d) Targeting is achieved	G4 PAMAM-D; DOX-PPI-FA	[3, 4]
3	Liposomes	Lipid bilayer memberane forming self assembled closed colloidal structures	(a) Biocompatible; (b) Longer duration of circulation; (c) Amphiphilic	DOX-p18-4; Pegylated liposomal of doxorubicin	[1, 4]
4	Carbon nanotubes	Benzene ring forming carbon cylindrical structure	(a) Multiple function; (b) Chemical modification; (c) Water soluble and biocompatible	SWNTs-PTX; SWNTs-siRNA
5	Nanorods	Metals or semiconducting materials forming rod shape structure.	(a) Efficient loading; (b) Increased surface area; (c) Biocompatible; (d) Specific tumor targeting	HER-PEG-GNRs; ZnO-NRs-DNR; PPDME-ZnO-NRs	[1, 4, 5]

PEG-b-p(LA-CO-MCG)-CISPLATIN, PEG-B-PCL (polyethylene glycol-paclitaxel), G4 PAMAM-D (G4 polyamidoamine dendrimer), DOX-PPI-FA (doxorubicin-polypropylene imine-folic acid), DOX-p18-4 (doxorubicin-peptide ligands), SWNTs-PTX (single-walled carbon nanotubes-paclitaxel), SWNTs- siRNA (single-walled carbon nanotubes-small interfering RNA), HER-PEG-GNRs (herceptin-polyethylene gold nanorods), ZnO-NRs-DNR (zinc oxide- nanorods daunorubicin), PPDME-ZnO-NRs (protoporphyrin dimethyl ester-zinc oxide-nanorods).