Association between Interleukin-1 Gene Single Nucleotide Polymorphisms and Ischemic Stroke Classified by TOAST Criteria in the Han Population of Northern China

Table 3

Genotype and allele frequencies of variants in the IL-1α-889 and IL-1β-511 gene, and association with ischemic stroke.

Groups	IL-1α-889 genotype					IL-1α-889 allele
	TT	CT	CC	𝑃	TT versus CT + CC; 𝑃, OR, 95% CI	𝐶	𝑇	𝑃	OR, 95% CI
Control, 𝑛 = 486	49 (10.1)	237 (48.8)	200 (41.1)			637	358
IS, 𝑛=440	63 (14.3)	232 (52.7)	145 (33.0)	0.016	0.065; 1.45, (0.97–2.15)	522	335	0.006	1.30, (1.08–1.58)
LAA, 𝑛=320	59 (18.4)	158 (49.4)	103 (32.2)	0.001	<0.05; 2.01, (1.34–3.0)	364	276	0.001	1.44, (1.18–1.78)
SVD, 𝑛=88	4 (4.5)	44 (50.0)	40 (45.5)	0.243	0.098; 0.42, (0.15–1.17)	124	52	0.204	0.80, (0.56–1.13)
CE, 𝑛=32	0 (0)	16 (50.0)	16 (50.0)	0.15	0.115; (—)	48	16	0.121	0.63, (0.36–1.13)
	IL-1β-511 genotype					IL-1β-511 allele
	TT	CT	CC	𝑃	TT versus CT + CC; 𝑃, OR, 95% CI	𝐶	𝑇	𝑃	OR, 95% CI
Control, 𝑛=486	117 (24.1)	261 (53.7)	108 (22.2)			477	495
IS, 𝑛=440	95 (21.6)	226 (51.3)	119 (27.1)	0.217	0.369; 0.87, (0.63–1.18)	464	416	0.116	0.86, (0.72–1.04)
LAA, 𝑛=320	64 (20.0)	168 (52.5)	88 (27.5)	0.158	0.175; 0.79, (0.56–1.11)	344	296	0.066	0.83, (0.68–1.01)
SVD, 𝑛=88	20 (22.7)	43 (48.9)	25 (28.4)	0.446	0.785; 0.93, (0.54–1.6)	93	83	0.358	0.86, (0.62–1.19)
CE, 𝑛=32	6 (18.8)	15 (46.9)	11 (34.3)	0.424	0.392; 0.73, (0.29–1.8)	27	37	0.286	0.29, (0.80–2.20)