Nonsmall Cell Lung Cancer Therapy: Insight into Multitargeted Small-Molecule Growth Factor Receptor Inhibitors

<table>Possible pathways for growth factor mediated tumorigenesis. Activation of receptor can lead to cell proliferation, survival, angiogenesis, and metastasis via four possible pathways; the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway, Ras/Raf/mitogen-activated protein kinase (MAPK) pathway, nitric oxide synthase (NOS), and prostaglandin (PG) involving phospholipase C<i>γ</i> (PLC<i>γ</i>)/protein kinase C (PKC) pathway and signal transducer and activator of transcription (STAT) pathway.</table>

BioMed Research International

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Figure 1: Nonsmall Cell Lung Cancer Therapy: Insight into Multitargeted Small-Molecule Growth Factor Receptor Inhibitors 