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BioMed Research International
Volume 2013, Article ID 970586, 14 pages
Review Article

Advanced MR Imaging of Gliomas: An Update

1Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, No. 155, Sec. 2, Linong Street, Taipei 112, Taiwan
2Department of Radiology, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Cheng-Kong Road, Neihu, Taipei 114, Taiwan
3Department of Electrical Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 106, Taiwan
4Imaging Research Center, Taipei Medical University, No. 250, Wu-Hsing Street, Taipei 110, Taiwan
5Department of Radiological Sciences, University of California at Irvine Medical Center, Irvine, 101 The City Drive South, Orange, CA 92868, USA

Received 9 January 2013; Revised 12 April 2013; Accepted 13 May 2013

Academic Editor: Shaoli Song

Copyright © 2013 Hung-Wen Kao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Recent advances in the treatment of cerebral gliomas have increased the demands on noninvasive neuroimaging for the diagnosis, therapeutic planning, tumor monitoring, and patient outcome prediction. In the meantime, improved magnetic resonance (MR) imaging techniques have shown much potentials in evaluating the key pathological features of the gliomas, including cellularity, invasiveness, mitotic activity, angiogenesis, and necrosis, hence, further shedding light on glioma grading before treatment. In this paper, an update of advanced MR imaging techniques is reviewed, and their potential roles as biomarkers of tumor grading are discussed.