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BioMed Research International
Volume 2013, Article ID 971760, 7 pages
Review Article

Revisiting the Cutaneous Impact of Oral Hormone Replacement Therapy

1Laboratory of Skin Bioengineering and Imaging, Department of Clinical Sciences, B23, University of Liège, 4000 Liège, Belgium
2Department of Dermatology, University Hospital St Jacques, 25030 Besançon, France
3San Gallicano Dermatological Institute, Department of Dermatology, 00144 Roma, Italy
4Department of Gynecology and Obstetrics, University Hospital of Liège, 4000 Liège, Belgium
5Department of Dermatopathology, Unilab Lg, University Hospital of Liège, 4000 Liège, Belgium
6Department of Dermatology, Regional Hospital of Huy, 4500 Huy, Belgium

Received 6 November 2013; Accepted 9 December 2013

Academic Editor: Philippe Delvenne

Copyright © 2013 Gérald E. Piérard et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Menopause is a key point moment in the specific aging process of women. It represents a universal evolution in life. Its initiation is defined by a 12-month amenorrhea following the ultimate menstrual period. It encompasses a series of different biologic and physiologic characteristics. This period of life appears to spot a decline in a series of skin functional performances initiating tissue atrophy, withering, and slackness. Any part of the skin is possibly altered, including the epidermis, dermis, hypodermis, and hair follicles. Hormone replacement therapy (oral and nonoral) and transdermal estrogen therapy represent possible specific managements for women engaged in the climacteric phase. All the current reports indicate that chronologic aging, climacteric estrogen deficiency, and adequate hormone therapy exert profound effects on various parts of the skin.