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BioMed Research International
Volume 2013 (2013), Article ID 981695, 11 pages
Review Article

Proregenerative Properties of ECM Molecules

Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden

Received 30 April 2013; Revised 4 July 2013; Accepted 7 August 2013

Academic Editor: Mauro S. G. Pavão

Copyright © 2013 Stefan Plantman. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


After traumatic injuries to the nervous system, regrowing axons encounter a complex microenvironment where mechanisms that promote regeneration compete with inhibitory processes. Sprouting and axonal regrowth are key components of functional recovery but are often counteracted by inhibitory molecules. This review covers extracellular matrix molecules that support neuron axonal outgrowth.