Heat Shock Protein 72 Expressing Stress in Sepsis: Unbridgeable Gap between Animal and Human Studies—A Hypothetical “Comparative” Study
Figure 1
(a) Preventive effect was achieved by all induction methods used irrespective of the challenge period or (b) time lapse between the sepsis insult and the Hsp72 induction: LPS, bacterial lipopolysaccharide; CLP, caecal ligation and puncture; iHsp72, inducible heat shock protein 72; Pre, pre-treatment; Post, posttreatment; both, trials with pre- and postexperiments; Con, concomitant; AdHSP, adenoviral vector Hsp72; exogHsp, exogenous Hsp72 preparations; Gln, glutamine; +, additional challenge; HS, heat stress; Hspgene, Hsp72 gene-transfected models.
