Vitamin B6-Dependent Enzymes in the Human Malaria Parasite Plasmodium falciparum: A Druggable Target?
Figure 2
Comparison of the active site of the human and plasmodial ornithine decarboxylases (ODC). (a) Structures of ODC inhibitors tested against Plasmodium. (b) A structural homology model of the positions of the P. falciparum ODC active site (the respective residues are illustrated in red; amino acid numbering refers to the bifunctional protein) as well as the bound cofactor PLP.
