Vitamin B6-Dependent Enzymes in the Human Malaria Parasite Plasmodium falciparum: A Druggable Target?
Figure 3
Three-dimensional structures of the AspATs. (a) The 3D structure of PfAspAT (PDB code: 3K7Y) highlighting the three major domains and the N-terminus (green) as additionally shown in the scheme below. (b) Comparison between the human AspAT (grey, PDB code: 3HLM) and the P. falciparum counterpart (dark grey). The respective N-terminal region is illustrated in black and the cofactor PLP in colour.
