Vitamin B6-Dependent Enzymes in the Human Malaria Parasite Plasmodium falciparum: A Druggable Target?

Table 1

Different classes of PLP-dependent enzymes according to [15, 33].

Group number	Enzyme class/activity	Representative enzymes
1	Aminotransferases and the amino-acid decarboxylases	Serine hydroxymethyltransferase (SHMT) and the aspartate aminotransferase (AspAT, prototype)
2	Replacement and elimination of Cβ-groups	Serine and threonine dehydratases and the tryptophan synthase (prototype)
3	Interconversion of L- and D-amino acids with a common folding (alpha/beta)8	Alanine racemase
4	Alanine aminotransferase	D-Alanine aminotransferase
5	Glycogen phosphorylase	Glycogen phosphorylase
6	5,6-Aminomutase	D-Lysine 5,6-aminomutase
7	2,3-Aminomutase	Lysine 2,3-aminomutase