Vitamin B6-Dependent Enzymes in the Human Malaria Parasite Plasmodium falciparum: A Druggable Target?

Table 2

PLP-dependent enzymes in Plasmodium.

EC-number	EC-name	PlasmoDB number	Annotation according to PlasmoDB	Pathway	Inhibitors	References
2.1.2.1	Glycine hydroxymethyltransferase	PFL1720w	Serine hydroxymethyltransferase	Folate metabolism	1843U89, AG331, AG337, D1694, GR1, pemetrexed, pyrimethamine, WR99210, methotrexate, glycine (competitively)	[34, 35]
2.3.1.37	5-Aminolevulinate synthase	PFL2210w	ALA synthase; (aminolevulinate synthase)	Tetrapyrrole biosynthesis	Aminomalonate, Ethanolamine, Hemin	[36]
2.6.1.1	Aspartate aminotransferase	PFB0200c	Aspartate aminotransferase	Amino acid and pyrimidine metabolism	Inhibited by his own N-terminal peptide	[37]
2.6.1.13	Ornithine aminotransferase	PFF0435w	Ornithine aminotransferase	Argnine metabolism	L-canaline	[38]
2.6.1.57	Aromatic amino-acid transaminase	PFB0200c	Aspartate aminotransferase	Amino acid and pyrimidine metabolism	—	—
4.1.1.17	Ornithine decarboxylase	PF10_0322	S-Adenosylmethionine decarboxylase/ornithine decarboxylase (bifunctional)	Polyamine biosynthesis	Alpha-difluoromethylornithine, alpha-difluoroornithine, CGP52622A, CGP54619A, putrescine (feedback control)	[39–44]
4.1.3.38	p-Aminobenzoic acid synthetase	PFI1100w	p-Aminobenzoic acid synthetase, putative	Folate biosynthesis	—	—
2.6.1.7	3-Hydroxykynurenine transaminase		Present in the insect vector: Anopheles	Xanthurenic acid is needed by the parasite for proliferation/; development	—	[45]
Putative PLP-dependent enzymes
2.3.1.50	Serine C-Palmitoyltransferase	PF14_0155	Serine C-Palmitoyltransferase	Sphingolipid metabolism	—	—
2.6.1.42	Branched-chain amino-acid aminotransferase	PF14_0557	“Conserved Plasmodium protein”	Pantothenate and CoA biosynthesis	—	—
2.8.1.7	Cysteine desulfurase	PF07_0068, MAL7P1.150	Cysteine desulfurase, putative	Iron-sulfur cluster synthesis	—	—
4.1.1.18	Lysine decarboxylase	PFD0285c, PFD0670c	Lysine decarboxylase, putative	Polyamine metabolism	—	—