Review Article
Vitamin B6-Dependent Enzymes in the Human Malaria Parasite Plasmodium falciparum: A Druggable Target?
Table 3
Comparison of the kinetic and inhibitory properties of ornithine decarboxylases.
| | P. falciparum* | M. musculus | T. gondii | T. brucei | References |
| Molecular mass (kDa) | 86.4 | 50–54 | 14 | 90 | [41, 46] | -value of L-ornithine (M) | 47.3 | 30–200 | — | 161 | [41, 47, 48] | -value of putrescine (M) | 50.4 | 600 | 0.92 | — | [41, 49] | -value of DFMO (M) | 87.6 | 39 | 0.025 | 220 | [41, 50, 51] | -value of CGP52622A (nM) | 20.4 | — | — | — | [41] | -value of CGP54619A (nM) | 7.9 | — | — | — | [41] | IC50-value of putrescine (M) | 157 | — | — | — | [41] | IC50-value of CGP52622A (nM) | 63.5 | 25 | — | — | [41] | IC50-value of CGP54619A (nM) | 25 | 10 | — | — | [41] |
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Data derived from the rPf hinge-ODC [41].
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