The Proximal Medial Sural Nerve Biopsy Model: A Standardised and Reproducible Baseline Clinical Model for the Translational Evaluation of Bioengineered Nerve Guides

Table 1

Patient selection: inclusion and exclusion criteria.

Inclusion criteria

Exclusion criteria

(i) Patients between 18 and ≤70 years of age; (ii) Patients with clinical and electrophysiological diagnosis of peripheral neuropathy with the indication for a nerve biopsy to establish the cause of the neuropathy

(i) Alcohol-related polyneuropathy (PNP); (ii) Paraneoplastic PNP; (iii) Ongoing immunosuppressive therapy; (iv) Malignant tumour; (v) Peripheral vascular disease; (vi) Collagenous diseases; (vii) Diabetes mellitus; (viii) Chronic venous insufficiency; (ix) Deep vein thrombosis; (x) Skin diseases of the lower extremity; (xi) Coagulopathy or anticoagulant therapy; (xii) Pregnancy; (xiii) Infectious diseases (i.e., HIV, hepatitis)