The Motile Breast Cancer Phenotype Roles of Proteoglycans/Glycosaminoglycans

Figure 1

Roles of PGs/GAGs on the breast cancer motile phenotype. (A) Complex formation between syndecan1 (SDC1) and integrin-α νβ3 activate focal adhesion kinase to facilitate breast cancer cell spreading. (B) The specific binding of SDC4, through its HS chains, to fibronectin activates FAK/protein kinase Ca (PKCa) downstream signaling to initiate focal adhesion formation. (C) Wnt5a attaches to glypican6 in order to enhance breast cancer cell invasive migration through the involvement of noncanonical Wnt pathway and JNK/p38 downstream signaling. (D) Complex formation among versican, EGFR, and Int-βL activates extracellular matrix regulated kinase (ERK1/2) signaling to promote breast cancer metastasis. (E) Binding of decorin to EGFR causes receptor internalization, degradation, and subsequent inhibition of EGFR signaling.