Efficacy of Annona squamosa L in the Synthesis of Glycosaminoglycans and Collagen during Wound Repair in Streptozotocin Induced Diabetic Rats
Figure 6
Masson’s trichrome staining for collagen in control and A. squamosa treated diabetic wound tissues from first, second, and third week, respectively (magnification 20x). Control (a) shows large number of proliferating blood vessels, whereas (b) treated tissue shows less collagen formation. In the second week, control (c) depicts adequate amount of blood vessels formation and collagen fibers and (d) treated tissue shows thick collagen fiber deposition under thin epithelial layer. In the third week, control (e) shows accumulation of loosely arranged collagen bundles at the wound site and (f) explores the completed epithelial layer with highly organized collagen deposition. IE: incomplete epithelialization, E: epithelialization, C: collagen, and BV: blood vessels. Scale bar: 50 μm.
