Comparative Diagnostic Accuracy of Ganglion Cell-Inner Plexiform and Retinal Nerve Fiber Layer Thickness Measures by Cirrus and Spectralis Optical Coherence Tomography in Relapsing-Remitting Multiple Sclerosis
Table 1
Clinical and demographic characteristics of healthy subjects and relapsing-remitting multiple sclerosis (RRMS) patients regarding optic neuritis (ON) antecedent. Differences were tested using generalized estimating equations accounting for sex, age, and within-patient intereye correlation.
Healthy subjects
RRMS
ON eyes
Non-ON eyes
(healthy versus RRMS)
(healthy versus ON eyes)
(healthy versus non-ON eyes)
(ON versus non-ON eyes)
Mean ± SD
Age (years)
0.077
0.008
0.077
0.302
Female (%)
40 (57%)
44 (63%)
14 (78%)
30 (58%)
0.387
0.627
0.363
0.552
LogMAR BCVA
0.006
0.023
0.115
0.083
EDSS score
N/A
N/A
N/A
N/A
0.873
Years since diagnosis
N/A
N/A
N/A
N/A
0.754
MD (in dB)
N/A
N/A
N/A
N/A
<0.001
Average pRNFL (Sp; in m)
<0.001
<0.001
<0.001
<0.001
Temporal pRNFL (Sp; in m)
<0.001
<0.001
<0.001
<0.001
PMB pRNFL (Sp; in m)
<0.001
<0.001
<0.001
<0.001
Average pRNFL (Ci; in m)
<0.001
<0.001
<0.001
<0.001
Temporal pRNFL (Ci; in m)
<0.001
<0.001
<0.001
<0.001
Average GCIPL (Ci; in m)
<0.001
<0.001
<0.001
<0.001
Minimum GCIPL (Ci; in m)
<0.001
<0.001
<0.001
<0.001
Superior GCIPL (Ci; in m)
<0.001
<0.001
<0.001
<0.001
Superonasal GCIPL (Ci; in m)
<0.001
<0.001
<0.001
<0.001
Inferonasal GCIPL (Ci; in m)
<0.001
<0.001
<0.001
<0.001
Inferior GCIPL (Ci; in m)
<0.001
<0.001
<0.001
<0.001
Inferotemporal GCIPL (Ci; in m)
<0.001
<0.001
<0.001
<0.001
Superotemporal GCIPL (Ci; in m)
<0.001
<0.001
<0.001
<0.001
SD: standard deviation; BCVA: best corrected visual acuity; EDSS: Expanded Disability Status Scale; MD: 24-2 SITA Standard Visual Field Mean Deviation; pRNFL: peripapillary retinal nerve fiber layer; Sp: Spectralis OCT; PMB: papillomacular bundle; Ci: Cirrus OCT; GCIPL: ganglion cell and inner plexiform layers.
