Comparative Diagnostic Accuracy of Ganglion Cell-Inner Plexiform and Retinal Nerve Fiber Layer Thickness Measures by Cirrus and Spectralis Optical Coherence Tomography in Relapsing-Remitting Multiple Sclerosis

Table 2

Number of eyes (and percentage) with abnormal results (yellow or red color-coded) in healthy and relapsing-remitting multiple sclerosis (RRMS) patients and according to optic neuritis (ON) antecedent. Statistical significance of associations was tested using generalized estimating equations accounting for sex, age, and within-patient intereye correlation.

Abnormal result	Healthy	RRMS	ON eyes	Non-ON eyes	(healthy versus RRMS)	(healthy versus ON eyes)	(healthy versus non-ON eyes)	(ON versus non-ON eyes)
	Average pRNFL (Sp)	5 (3.6)	49 (35.0)	20 (55.6)					29 (27.9)	<0.001	<0.001	<0.001	<0.001
Temporal pRNFL (Sp)	5 (3.6)	65 (46.4)	22 (61.1)	43 (41.3)	<0.001	<0.001	<0.001	<0.001
PMB pRNFL (Sp)	4 (2.9)	43 (30.7)	17 (47.22)	26 (25.0)	<0.001	<0.001	<0.001	0.012
Average pRNFL (Ci)	9 (6.4)	46 (32.9)	19 (52.8)	27 (26.0)	<0.001	<0.001	0.001	0.001
Temporal pRNFL (Ci)	2 (1.4)	49 (35.0)	24 (66.7)	25 (24.0)	<0.001	<0.001	<0.001	<0.001
Average GCIPL (Ci)	8 (5.7)	65 (46.4)	25 (69.4)	40 (38.5)	<0.001	<0.001	<0.001	<0.001
Minimum GCIPL (Ci)	7 (5.0)	67 (47.9)	28 (77.8)	39 (37.5)	<0.001	<0.001	<0.001	<0.001
Superior GCIPL (Ci)	8 (5.7)	63 (45.0)	26 (72.2)	37 (35.6)	<0.001	<0.001	<0.001	<0.001
Superonasal GCIPL (Ci)	4 (2.9)	66 (47.1)	26 (72.2)	40 (38.5)	<0.001	<0.001	<0.001	<0.001
Inferonasal GCIPL (Ci)	4 (2.9)	58 (41.4)	27 (75.0)	31 (29.8)	<0.001	<0.001	<0.001	<0.001
Inferior GCIPL (Ci)	2 (1.4)	50 (35.7)	23 (63.9)	27 (26.0)	<0.001	<0.001	<0.001	<0.001
Inferotemporal GCIPL (Ci)	6 (4.3)	55 (39.3)	22 (61.1)	33 (31.7)	<0.001	<0.001	<0.001	0.002
Superotemporal GCIPL (Ci)	12 (8.9)	64 (45.7)	25 (69.4)	39 (37.5)	<0.001	<0.001	<0.001	<0.001

pRNFL: peripapillary retinal nerve fiber layer; Sp: Spectralis OCT; PMB: papillomacular bundle; Ci: Cirrus OCT; GCIPL: ganglion cell and inner plexiform layers.