Comparative Diagnostic Accuracy of Ganglion Cell-Inner Plexiform and Retinal Nerve Fiber Layer Thickness Measures by Cirrus and Spectralis Optical Coherence Tomography in Relapsing-Remitting Multiple Sclerosis

Table 3

Estimated sensitivity and specificity of different optic coherence tomography measures for retinal thickness changes detection in eyes of patients with relapsing-remitting multiple sclerosis () and from healthy control subjects () using latent class analysis. Model A: temporal pRNFL thickness as measured by Cirrus OCT; estimated prevalence of retinal thickness changes in the sample was 23.42%; 95% confidence interval (95CI) 18.50 to 29.17%. Model B: temporal pRNFL thickness as measured by Spectralis OCT; estimated prevalence of retinal thickness changes in the sample was 24.25%; 95% confidence interval (95CI) 19.26 to 30.04%.

	Sensitivity		Specificity
	Estimate	95CI	Estimate	95CI
Model A
Cirrus average GCIPL	96.34%	76.11 to 99.54%	97.05%	92.77 to 98.83%
Cirrus minimum GCIPL	98.43%	64.61 to 99.95%	95.81%	91.00 to 98.10%
Cirrus temporal pRNFL	58.41%	45.82 to 70.00%	93.91%	89.56 to 96.52%
Best corrected visual acuity	6.14%	2.32 to 15.30%	98.59%	95.72 to 99.54%
Model B
Cirrus average GCIPL	97.15%	76.94 to 99.71%	97.61%	93.16 to 99.19%
Cirrus minimum GCIPL	96.41%	81.48 to 99.39%	95.43%	90.80 to 97.78%
Spectralis temporal pRNFL	69.69%	57.14 to 79.86%	92.70%	88.01 to 95.65%
Best corrected visual acuity	6.08%	2.30 to 15.15%	98.55%	95.58 to 99.53%

GCIPL: ganglion cell-inner plexiform layers; pRNFL: peripapillary retinal nerve fiber layer.