Comparative Diagnostic Accuracy of Ganglion Cell-Inner Plexiform and Retinal Nerve Fiber Layer Thickness Measures by Cirrus and Spectralis Optical Coherence Tomography in Relapsing-Remitting Multiple Sclerosis

Table 4

Standardized correlation coefficients between OCT measurements and neurologic and visual function parameters in eyes of patients with relapsing-remitting multiple sclerosis, calculated using generalized estimating equations accounting for sex, age, and within-patient intereye correlation ().

	BCVA	MD	EDSS	Disease duration
Cirrus average pRNFL	0.286*	0.418*	−0.014	−0.233^‡
Cirrus temporal pRNFL	−0.013	0.062	0.001	−0.141
Spectralis average pRNFL	0.314*	0.360*	0.033	−0.228^‡
Spectralis temporal pRNFL	0.122^‡	0.268^†	−0.101	−0.261^‡
Spectralis PMB pRNFL	0.125^‡	0.209^‡	−0.066	−0.275^†
GCIPL average	0.226*	0.513*	−0.178	−0.262^‡
GCIPL minimum	0.204^†	0.412*	−0.161	−0.299^†
Non-ON eyes ( = 104)
Cirrus average pRNFL	−0.019	0.098	0.033	−0.253^‡
Cirrus temporal pRNFL	−0.270^‡	−0.030	−0.046	−0.146
Spectralis average pRNFL	0.210*	0.145	0.109	−0.274^‡
Spectralis temporal pRNFL	−0.025	0.093	−0.092	−0.284^†
Spectralis PMB pRNFL	0.002	0.083	−0.040	−0.332^†
GCIPL average	−0.062	0.109	−0.113	−0.297^‡
GCIPL minimum	0.029	0.138	−0.092	−0.314^†
ON eyes ( = 36)
Cirrus average pRNFL	0.188	0.161	−0.173	0.012
Cirrus temporal pRNFL	−0.043	0.001	0.105	−0.013
Spectralis average pRNFL	0.175	0.149	−0.151	0.109
Spectralis temporal pRNFL	0.112	0.030	−0.195	0.065
Spectralis PMB pRNFL	0.059	−0.022	−0.120	0.097
GCIPL average	0.145	0.133	−0.429^†	−0.079
GCIPL minimum	0.144	0.120	−0.421^‡	−0.227

; ; .
OCT: optic coherence tomography; BCVA: best corrected visual acuity; MD: Goldman 24-2 SITA standard visual field mean deviation; EDSS: Expanded Disability Status Scale; pRNFL: peripapillary retinal nerve fiber layer; PMB: papillomacular bundle; GCIPL: ganglion cell and inner plexiform layers; ON: optic neuritis.