BioMed Research International / 2014 / Article / Tab 1

Review Article

A Review of Bioactive Release from Nerve Conduits as a Neurotherapeutic Strategy for Neuronal Growth in Peripheral Nerve Injury

Table 1

Salient features of an ideal nerve conduit.

Conduit features and requirementsImportance and functionReferences

Mechanical attributes(i) Should not bend, buckle, or kink postimplantation
(ii) Be able to maintain structural integrity to support tissue growth
[2, 16, 24]
(i) Overly pliable conduits are unable to withstand pressure from growing and surrounding tissues
(ii) Rigid conduits may cause compression and damage to growing and surrounding tissues
For example, blood vessels and nerve stumps
(iii) Sufficient flexibility to withstand body movements, particularly at joint sites
[24, 25, 30]

Biodegradation rate(i) Should degrade at a rate corresponding to tissue regeneration
(ii) Premature disintegration removes provision of support structure
(iii) Lengthy degradation may cause compression and inflammation of newly generated tissues
[30, 31]

Semipermeability(i) Should allow exchange of oxygen and nutrients and elimination of waste products between internal and external environment of conduit
(ii) Prevent infiltration of inflammatory cells and fibrotic tissue
(iii) Prevent escape of neurotrophic growth factors secreted by damaged nerve stumps and from system
[16, 24, 30]

Physical and 3D guidance cues(i) Cylindrical and channel-based structures for growth cone guidance
(ii) Prevent axonal misdirection during regeneration towards distal nerve
[15, 24, 29]

Ability to deliver growth factors or Schwann cells(i) Enhancement of functional recovery and axonal regeneration
(ii) Important for neuronal survival and differentiation
(iii) Schwann cells for support of axon regeneration and remyelination
[22, 30, 3235]

Processing requirementsMaintenance of stability during handling, sterilization, storage, and surgical procedures[24]