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BioMed Research International
Volume 2014, Article ID 137049, 9 pages
http://dx.doi.org/10.1155/2014/137049
Research Article

Negative Regulation of GADD34 on Myofibroblasts during Cutaneous Wound Healing

Department of Immunology, Nagoya University Graduate School of Medicine, 65 Turumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan

Received 7 July 2014; Revised 4 August 2014; Accepted 5 August 2014; Published 19 August 2014

Academic Editor: Ji Wu

Copyright © 2014 Lintao Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. J. Singer and R. A. F. Clark, “Cutaneous wound healing,” The New England Journal of Medicine, vol. 341, no. 10, pp. 738–746, 1999. View at Publisher · View at Google Scholar · View at Scopus
  2. I. Darby, O. Skalli, and G. Gabbiani, “α-Smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing,” Laboratory Investigation, vol. 63, no. 1, pp. 21–29, 1990. View at Google Scholar · View at Scopus
  3. G. Gabbiani, “The myofibroblast in wound healing and fibrocontractive diseases,” Journal of Pathology, vol. 200, no. 4, pp. 500–503, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. G. Serini and G. Gabbiani, “Mechanisms of myofibroblast activity and phenotypic modulation,” Experimental Cell Research, vol. 250, no. 2, pp. 273–283, 1999. View at Publisher · View at Google Scholar · View at Scopus
  5. J. J. Tomasek, G. Gabbiani, B. Hinz, C. Chaponnier, and R. A. Brown, “Myofibroblasts and mechano: regulation of connective tissue remodelling,” Nature Reviews Molecular Cell Biology, vol. 3, no. 5, pp. 349–363, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Desmoulière, M. Redard, I. Darby, and G. Gabbiani, “Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar,” The American Journal of Pathology, vol. 146, no. 1, pp. 56–66, 1995. View at Google Scholar · View at Scopus
  7. B. Hinz, “Formation and function of the myofibroblast during tissue repair,” Journal of Investigative Dermatology, vol. 127, no. 3, pp. 526–537, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Desmouliere, A. Geinoz, F. Gabbiani, and G. Gabbiani, “Transforming growth factor-β1 induces α-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts,” Journal of Cell Biology, vol. 122, no. 1, pp. 103–111, 1993. View at Publisher · View at Google Scholar · View at Scopus
  9. I. Novoa, Y. Zhang, H. Zeng, R. Jungreis, H. P. Harding, and D. Ron, “Stress-induced gene expression requires programmed recovery from translational repression,” EMBO Journal, vol. 22, no. 9, pp. 1180–1187, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. I. Novoa, H. Zeng, H. P. Harding, and D. Ron, “Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2α,” Journal of Cell Biology, vol. 153, no. 5, pp. 1011–1021, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. M. H. Brush and S. Shenolikar, “Control of cellular GADD34 levels by the 26S proteasome,” Molecular and Cellular Biology, vol. 28, no. 23, pp. 6989–7000, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. T. Hasegawa, H. Xiao, F. Hamajima, and K.-I. Isobe, “Interaction between DNA-damage protein GADD34 and a new member of the Hsp40 family of heat shock proteins that is induced by a DNA-damaging reagent,” Biochemical Journal, vol. 352, no. 3, pp. 795–800, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Watanabe, Y. Tambe, H. Inoue et al., “GADD34 inhibits mammalian target of rapamycin signaling via tuberous sclerosis complex and controls cell survival under bioenergetic stress,” International Journal of Molecular Medicine, vol. 19, no. 3, pp. 475–483, 2007. View at Google Scholar · View at Scopus
  14. M. Hollander, M. Sheikh, K. Yu et al., “Activation of Gadd34 by diverse apoptotic signals and suppression of its growth inhibitory effects by apoptotic inhibitors,” International Journal of Cancer, vol. 96, pp. 22–31, 2001. View at Google Scholar
  15. M. C. Hollander, Q. Zhan, I. Bae, and A. J. Fornace Jr., “Mammalian GADD34, an apoptosis- and DNA damage-inducible gene,” Journal of Biological Chemistry, vol. 272, no. 21, pp. 13731–13737, 1997. View at Publisher · View at Google Scholar · View at Scopus
  16. H. T. Adler, R. Chinery, D. Y. Wu et al., “Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins,” Molecular and Cellular Biology, vol. 19, no. 10, pp. 7050–7060, 1999. View at Google Scholar · View at Scopus
  17. W. Shi, C. Sun, B. He et al., “GADD34-PP1c recruited by Smad7 dephosphorylates TGFβ type I receptor,” Journal of Cell Biology, vol. 164, no. 2, pp. 291–300, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. E. Kojima, A. Takeuchi, M. Haneda et al., “The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient mice,” The FASEB Journal, vol. 17, no. 11, pp. 1573–1575, 2003. View at Publisher · View at Google Scholar
  19. A. Desmoulière, C. Chaponnier, and G. Gabbiani, “Tissue repair, contraction, and the myofibroblast,” Wound Repair and Regeneration, vol. 13, no. 1, pp. 7–12, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. R. Abe, S. C. Donnelly, T. Peng, R. Bucala, and C. N. Metz, “Peripheral blood fibrocytes: differentiation pathway and migration to wound sites,” Journal of Immunology, vol. 166, no. 12, pp. 7556–7562, 2001. View at Publisher · View at Google Scholar · View at Scopus
  21. N. C. Direkze, S. J. Forbes, M. Brittan et al., “Multiple organ engraftment by bone-marrow-derived myofibroblasts and fibroblasts in bone-marrow-transplanted mice,” Stem Cells, vol. 21, no. 5, pp. 514–520, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. R. Higashiyama, S. Nakao, Y. Shibusawa et al., “Differential contribution of dermal resident and bone marrow-derived cells to collagen production during wound healing and fibrogenesis in mice,” Journal of Investigative Dermatology, vol. 131, no. 2, pp. 529–536, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. R. M. Gallucci, E. G. Lee, and J. J. Tomasek, “IL-6 modulates alpha-smooth muscle actin expression in dermal fibroblasts from IL-6-deficient mice,” Journal of Investigative Dermatology, vol. 126, no. 3, pp. 561–568, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. T. Hasegawa, H. Xiao, and K. Isobe, “Cloning of a GADD34-like gene that interacts with the zinc-finger transcription factor which binds to the p21(WAF) promoter,” Biochemical and Biophysical Research Communications, vol. 256, no. 1, pp. 249–254, 1999. View at Publisher · View at Google Scholar · View at Scopus
  25. K. Minami, Y. Tambe, R. Watanabe et al., “Suppression of viral replication by stress-inducible GADD34 protein via the mammalian serine/threonine protein kinase mTOR pathway,” Journal of Virology, vol. 81, no. 20, pp. 11106–11115, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. H. Sugimoto, T. M. Mundel, M. W. Kieran, and R. Kalluri, “Identification of fibroblast heterogeneity in the tumor microenvironment,” Cancer Biology and Therapy, vol. 5, no. 12, pp. 1640–1646, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. C. A. Fielding, G. W. Jones, R. M. McLoughlin et al., “Interleukin-6 signaling drives fibrosis in unresolved inflammation,” Immunity, vol. 40, pp. 40–50, 2014. View at Google Scholar