Effects of Stress and MDMA on Hippocampal Gene Expression

Table 1

Stress suppressed genes that are resistant to consecutive MDMA exposure.

Entrez ID	Symbol	Gene name		No MDMA		MDMA
			Average intensity	−Fold change	𝑃 value	−Fold change	𝑃 value
361619	MGC72973	Beta-glo	744.46	−1.62	0.02	−1.58	0.01
287167	LOC287167	Globin, alpha	512.31	−1.61	0.02	−1.29	0.04
24440	Hbb	Hemoglobin, beta	1327.73	−1.60	0.02	−1.55	0.00
499947	Cbln4	Cerebellin 4 precursor	103.48	−1.51	0.04	−1.78	0.00
29139	Dcn	Decorin	203.33	−1.45	0.04	−1.43	0.00
300850	Gsta4	Glutathione S-transferase, alpha 4	112.68	−1.41	0.03	−1.49	0.01
362489	Runx1t1	Runt-related transcription factor 1; translocated to, 1	152.25	−1.36	0.04	−1.22	0.00
313729	Errfi1	ERBB receptor feedback inhibitor 1	725.49	−1.35	0.00	1.21	0.00
252917	Nr1d1	Nuclear receptor subfamily 1, group D, member 1	347.48	−1.34	0.00	−1.45	0.00
685671	LOC685671	Similar to myocyte enhancer factor 2C	1233.46	−1.31	0.02	−1.34	0.00
24330	Egr1	Early growth response 1	286.86	−1.31	0.02	−1.26	0.03
289440	Abhd7	Abhydrolase domain containing 7	125.15	−1.30	0.02	−1.26	0.00
308831	Odz4	Odd Oz/ten-m homolog 4 (Drosophila)	162.69	−1.26	0.01	−1.25	0.00
316351	Npas2	Neuronal PAS domain protein 2	255.91	−1.25	0.01	−1.24	0.00
114858	Shc3	Src homology 2 domain-containing transforming protein C3	301.74	−1.24	0.00	−1.26	0.00
310358	RGD1308448	Similar to RIKEN cDNA B130016O10 gene	169.03	−1.23	0.03	−1.22	0.00
294250	Bat2	HLA-B associated transcript 2	266.79	−1.22	0.01	−1.22	0.00
24309	Dbp	D site albumin promoter binding protein	961.48	−1.21	0.00	−1.28	0.00
291356	RGD1563437	Similar to KIAA1217	116.04	−1.21	0.04	−1.22	0.00
116470	Stx1a	Syntaxin 1A (brain)	436.23	−1.20	0.04	−1.27	0.00

Stress suppressed genes that are resistant to consecutive MDMA exposure. The average intensity of all genes shown is above threshold. All −fold changes and 𝑃 values are significantly differentially expressed as defined in Section 2.