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BioMed Research International
Volume 2014, Article ID 143192, 6 pages
http://dx.doi.org/10.1155/2014/143192
Research Article

Alleviation of Plasma Homocysteine Level by Phytoestrogen -Zearalanol Might Be Related to the Reduction of Cystathionine -Synthase Nitration

1Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men Wai, Beijing 100069, China
2Beijing Key Laboratory of Metabolic Disorders Related Cardiovascular Diseases, No. 10 Xitoutiao, You An Men Wai, Beijing 100069, China
3Department of Pathology, Beijing Luhe Hospital, Capital Medical University, 82 Xinhuanan Road, Tongzhou District, Beijing 101149, China
4Beijing Stomatological Hospital, Capital Medical University, 4 Tiantanxili, Dongcheng District, Beijing 100050, China

Received 2 January 2014; Revised 24 February 2014; Accepted 24 February 2014; Published 24 March 2014

Academic Editor: Kota V. Ramana

Copyright © 2014 Hui Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hyperhomocysteinemia is strongly associated with cardiovascular diseases. Previous studies have shown that phytoestrogen -zearalanol can protect cardiovascular system from hyperhomocysteinemia and ameliorate the level of plasma total homocysteine; however, the underlying mechanisms remain to be clarified. The aim of this research is to investigate the possible molecular mechanisms involved in ameliorating the level of plasma homocysteine by -zearalanol. By the successfully established diet-induced hyperhomocysteinemia rat models, we found that, after -zearalanol treatment, the activity of cystathionine -synthase, the key enzyme in homocysteine metabolism, was significantly elevated and level of nitrative stress in liver was significantly reduced. In correlation with this, results also showed a decreased nitration level of cystathionine -synthase in liver. Together data implied that alleviation of plasma homocysteine level by phytoestrogen -zearalanol might be related to the reduction of cystathionine -synthase nitration.