An Overview of the Spindle Assembly Checkpoint Status in Oral Cancer

Table 1

Expression levels of core spindle assembly checkpoint components in oral squamous cell carcinoma.

SAC protein	Samples	Expression levels	References
Cdc20	OSCC cell lines (7 out of 10); Primary HNSCC (7 out of 10 cases)	Overexpression	[58]
	OSCC cell lines (2 of 7)	Overexpression	[59]
	OSCC (37 out of 65 cases)	Overexpression	[61]
Mad2	OSCC cell lines (7 out of 7)	Underexpression	[59]
BubR1	OSCC (43 out of 43 cases); Oral PMD (75 out of 77 cases)	Overexpression	[62]
	OSCC^IS (15 out of 20 cases); OSCC^WT(19 out of 27 cases); OSCC^W(18 out of 23 cases); Cervical LN (15 out of 23 cases)	Overexpression	[63]
	OL^NM (16 out of 16 cases)	Underexpression
	OSCC (11 out of 49 cases)	Overexpression	[64]
Aurora B	OSCC cell lines (7 out of 7); OSCC (71 out of 101)	Overexpression	[66]
	OSCC (40 out of 40 cases)	Overexpression	[67]
	OSCC (162 out of 215 cases)	Overexpression	[68]

PMD: potentially malignant disorders; OSCC^IS: in situ OSCC; OSCC^WT: invasive OSCC without metastasis; OSCC^W: invasive OSCC with metastasis; cervical LN: lymph nodes; OL^NM: nonmalignant oral lesions.