Review Article

Caffeic Acid Phenethyl Ester and Therapeutic Potentials

Table 3

Applications of caffeic acid phenethyl ester against chemotherapy-induced toxicities.

NumberToxicity inducing drugsToxicitySubjectReferences

1Doxorubicin toxicityNephrotoxicityRats[111]
2CardiotoxicityRats[112]
3Neuronal oxidant injuryRats[113]
4Medulloblastoma cell toxicityHuman[114]

5Cisplatin toxicityNephrotoxicityRats[63]
6Bone marrow cell toxicityRats[115]
7HepatotoxicityRats[116]
8HepatotoxicityRats[117]
9OtotoxicityRats[114]

10Methotrexate toxicityNeuronal oxidant injuryHuman[118]
11NephrotoxicityRats[119]
12Cerebellar oxidative stressRats[120]
13Testicular toxicityRats[121]
14NephrotoxicityRats[122]
15Hepatorenal oxidative injuryRats[123]
16Hepatorenal oxidative injuryRats[124]

17Bleomycin toxicityLung fibrosisRats[124, 125]

18Tamoxifen toxicityHepatotoxicityRats[126]