Glucose, Insulin, and Oxygen Interplay in Placental Hypervascularisation in Diabetes Mellitus
Table 1
In vitro expression of receptors of proangiogenic factors in the fetoplacental endothelium in normal third trimester human placenta.
Angiogenic factors
Receptors of angiogenic factors
Gene symbol
Gene symbol
RefSeq ID
Mean intensity
Sd
VEGFA/PlGF
FLT1/VEGFR1
NM_002019
9.5
0.59
VEGFB
KDR/VEGFR2
NM_002253
10.5
1.43
FGF1/FGF2
FGFR1
NM_023110
9.5
0.25
FGFR2
NM_000141
5.3
0.11
FGFR3
NM_000142
6.8
0.13
FGFR4
NM_213647
6.1
0.09
ANGPT1
TIE1
NM_005424
10.8
0.34
ANGPT2
TEK/TIE2
NM_000459
10.1
0.61
EPO
EPOR
NM_000121
7.6
0.15
TNFA
TNFR1
NM_001065
10.8
0.15
TNFR2
NM_001066
8.6
0.57
IL6
IL6R
NM_000565
6.7
0.28
INS
INSR
NM_000208
6.4
0.70
IGF1
IGF1R
NM_000875
7.5
0.54
IGF2
IGF2R
NM_000876
9.3
0.48
LEP
LEPR
NM_002303
8.51
0.17
ADIPOQ
ADIPOR1
NM_015999
11.6
0.11
ADIPOR2
NM_024551
9.6
0.18
Mean mRNA signal intensities from arterial () and venous () endothelial cells measured by Affymetrix GeneChip Human 1.0 ST arrays (Cvitic et al., unpublished data). Signal intensities range from 1 to 13. Sd: standard deviation.
