BioMed Research International

Review Article

MicroRNA as New Tools for Prostate Cancer Risk Assessment and Therapeutic Intervention: Results from Clinical Data Set and Patients’ Samples

Table 1

MicroRNAs associated with PCa diagnosis.


References	Sample type	miRs deregulated	miRs selected as candidate biomarkers

Taylor et al. (2010) [24]	113 PCa tissues 28 normal tissues	Large screening study	Taylor et al. 10.1016/j.ccr.2010.05.026

Volinia et al. (2006) [31]	56 PCa tissues 7 normal tissues	39 upregulated 6 downregulated	Volinia et al. 10.1073/pnas.0510565103;

Ambs et al. (2008) [32]	60 microdissected tumor tissues 16 normal tissues	21 upregulated 21 downregulated	miR-32, miR-26a, miR-181a, miR-93, miR-196a, miR25, miR-92 and let-7i	↑

Porkka et al. (2007) [38]	5 hormone-naïve PCa tissues 4 HRPC tissues 4 BPH tissues	14 upregulated 37 downregulated	PCa: miR-16, miR-99 and let-7 family	↓
			HRPC: miR-205, miR-100 and miR-30	↓

Ozen et al. (2008) [43]	16 PCa tissues and 10 normal tissues	9 upregulated 76 downregulated	Let-7, miR-30, miR-16	↓

Martens-Uzunova et al. (2012) [44]	102 PCa tissues and normal adjacent tissues	54 deregulated	miR-205	↓

Larne et al. (2013) [45]	49 PCa tissues 25 normal tissues	7 deregulated	miR-96-5p, miR-183-5p	↑
			miR-145-5, miR-221-5p	↓
			(combined in miQ score)

Moltzahn et al. (2011) [46]	Serum samples from PCa () and HD ()	6 upregulated 4 downregulated	miR-20b, miR-874, miR-1274a, miR-1207-5p, miR-93, miR-106a	↑
			miR-223, miR-26b, miR-30c, miR-24	↓

Bryant et al. (2012) [48]	Plasma samples from PCa () and HD () Urine samples from PCa () and HD ()	12 deregulated	miR-107, miR-574-3p	↑

Srivastava et al. (2013) [49]	40 PCa tissues and 40 normal adjacent tissues. Urine samples from PCa () and HD ()	2 downregulated	miR-205, miR-214	↓

Haj-Ahmad et al. (2014) [50]	Urine samples from PCa () BPH () patients and HD ()	17 deregulated (only 7 selected for further analysis)	miR-1825 (only in PCa)	↑
			miR-484 (in PCa and BPH)	↓

Schaefer et al. (2010) [54]	76 PCa and adjacent normal tissues	5 upregulated 10 downregulated	miR-96, miR-182, miR-182* miR-183 and miR-375	↑
			miR-16, miR-31, miR-125b, miR-145, miR-149, miR-181b, miR-184, miR-205, miR-221, miR-222	↓

PCa: prostate cancer; HRPC: hormone refractory prostate cancer; BPH: benign prostatic hyperplasia; HD: healthy donors, FFPE: formalin-fixed, paraffin-embedded.