BioMed Research International / 2014 / Article / Tab 2

Review Article

MicroRNA as New Tools for Prostate Cancer Risk Assessment and Therapeutic Intervention: Results from Clinical Data Set and Patients’ Samples

Table 2

MicroRNAs associated with PCa prognosis.

References Sample typeClinical parametersmiRs deregulatedmiRs selected as candidate biomarkers

Taylor et al. (2010) [24]113 PCa tissues
28 normal tissues
Large screening studyTaylor et al. 10.1016/j.ccr.2010.05.026

Martens-Uzunova et al. (2012) [44]102 PCa tissues and normal adjacent tissuesHigh risk biochemical recurrence12 upregulated
13 downregulated
miR-19a, miR-130a,
miR-27, miR-143,

Tong et al. (2009) [53] 40 FFPE prostatectomy
(20 without early BCR 20 with early BCR)
Biochemical recurrence2 upregulated
4 downregulated
miR-135, miR-194
(40% of case)
miR-145, miR-221,

Schaefer et al. (2010) [54]76 PCa and adjacent normal tissuesBiochemical recurrence5 upregulated
10 downregulated

Hulf et al. (2013) [55]149 PCa and 30 matched normal tissuesBiochemical recurrence1 downregulatedmiR-205

Schubert et al. (2013) [62]BCR tissues and disease-free tissuesBiochemical recurrence2 downregulatedlet-7b and let-7c

Leite et al. (2011) [66]21 frozen BCR tissues
28 frozen disease-free tissues
Biochemical recurrence4 upregulatedmiR-100

Karatas et al. (2014) [72]82 PCa tissues
(41 BCR and 41 disease-free)
Biochemical recurrence3 downregulatedmiR-1, miR-133b

Selth et al. (2013) [102]Serum samples from PCa patients (BCR = 8)
disease-free = 8)
Biochemical recurrence3 upregulated miR-194 miR-146-3p

Shen et al. (2012) [87]Plasma samples from PCa ()Castration resistance2 upregulatedmiR-21, miR-145

Jalava et al. (2012) [90]28 primary PCa tissues
14 CRPC tissues
12 BPH tissues
Castration resistance4 upregulated
3 downregulated
miR-32, miR-148a,
miR-590-5p, miR-21
miR-99a, miR-99b,

Peng et al. (2011) [94]6 primary PCa tissues
7 bone metastatic tissues
Metastasis5 downregulatedmiR-508-5p, miR-143,
miR-145, miR-33a,

Saini et al. (2011) [95]36 PCa tissues
8 metastatic tissues
8 normal tissues
Metastasis1 downregulatedmiR-203

Mitchell et al. (2008) [19]Serum samples from metastatic PCa () and age-matched HD ()Metastasis6 deregulatedmiR-141

Brase et al. (2011) [100]Serum samples from localized PCa () and metastatic PCa ()Metastasis5 upregulatedmiR-141, miR-375

Bryant et al. (2012) [48]Serum samples from PCa () and metastatic PCa ()
Plasma samples from PCa () and metastatic PCa ()
Metastasis2 upregulatedmiR-141 and miR-375

Nguyen et al. (2013) [103] Serum samples from localized PCa () and metastatic CRPC ()Castration resistance3 upregulated
1 downregulated
miR-141, miR-375,

Zhang et al. (2011) [88]Serum samples from localized PCa (), ADPC (), CRPC DTX treated () and BPH ()Castration resistance1 upregulatedmiR-21

FFPE: formalin-fixed, paraffin-embedded, BCR: biochemical recurrence, Pca: prostate cancer, CRPC: castration resistant prostate cancer, BPH: benign prostatic hyperplasia, HD: healthy donors.

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