Insulin Receptor Substrate-1 (IRS-1) Gly927Arg: Correlation with Gestational Diabetes Mellitus in Saudi Women

Table 2

Demographic characteristics of the pregnant women.

	GDM Cases (𝑛=200)	Non-GDM (𝑛=300)	𝑃 value
Age (years)	32.43±5.79	31.36±6.02	0.55
Weight (Kg)	77.1±13.34	74.85±12.09	0.12
Height (m^2)	158.51±5.92	157.81±5.31	0.08
BMI (kg/m^2)	34.43±4.68	33.36±4.28	0.16
Mean gestational age	30.27±5.77	NA	NA
FBS (mmol/L)	5.0±0.93	4.5±0.87	<0.001
PPBG (mmol/L)	6.8±2.0	4.9±1.8	0.001
GCT (mmol/L)	9.5±1.8	6.3±1.5	<0.001
OGTT (Fasting hour)	5.2±1.18	4.5±0.87	<0.001
OGTT (1st hour)	10.7±1.8	8.0±1.7	<0.001
OGTT (2nd hour)	9.2±1.8	6.7±1.6	<0.001
OGTT (3rd hour)	5.6±1.7	4.5±1.3	<0.001
TG (mmol/L)	2.3±1.8	1.7±0.98	<0.001
TC (mmol/L)	5.7±1.2	5.2±1.0	<0.001
HDL-C (mmol/L)	0.92±0.38	0.64±0.24	<0.001
LDL-C (mmol/L)	3.7±0.93	3.7±1.0	0.82
Family history of T2DM (𝑛 %)	120 (60%)	55 (18.3%)	<0.001
Family history of GDM (𝑛 %)	46 (23%)	13 (4.3%)	<0.001
𝑅𝑥 (Diet/Insulin)	180 (90%)/20 (10%)	NA	NA

All continuous variables represented by mean ± standard deviation. Independent sample 𝑡-test is done comparing GDM and non-GDM subjects. Categorical variables compared using chi-square analysis. A 𝑃<0.05 was considered significant. NA: not applicable/not analyzed.