Hot Melt Extruded Amorphous Solid Dispersion of Posaconazole with Improved Bioavailability: Investigating Drug-Polymer Miscibility with Advanced Characterisation

Table 1

HME process parameters and drug-polymer composition of prepared formulations.

Formulation codes	Batch size (gm)	Formulation composition						Extrusion temp. (°C) (speed 50 rpm for all)	Residence time (min)
		Drug (gm)	Sol (gm)	PEG400 (gm)	LF127 (gm)	LF68 (gm)	TPGS (gm)
PZ1	60	30	29	1	—	—	—	115	7–9
PZ2	60	30	29	—	1	—	—	114	9–11
PZ3	60	30	29	—	—	1	—	118	10–12
PZ4	60	30	29	—	—	—	1	112	8–10