Hot Melt Extruded Amorphous Solid Dispersion of Posaconazole with Improved Bioavailability: Investigating Drug-Polymer Miscibility with Advanced Characterisation

Table 2

Solubility parameter calculation for drug polymer compatibility.

Drug and polymers	𝛿hi	𝛿di	𝛿pi	𝛿	Δ𝛿 MPa^1/2 (not ≥7)	Drug-polymer compatibility
PCZ	9.04	3.11	15.93	18.57 (a)	—	—
Sol + PEG400	(19.43 + 9.60)/2			14.51 (b)	(a − b) = 4.06	Miscible
Sol + LF127	(19.43 + 11.20)/2			15.31 (c)	(a − c) = 3.26	Miscible
Sol + LF68	(19.43 + 12.37)/2			15.9 (d)	(a − d) = 2.67	Miscible
Sol + TPGS	(19.43 + 8.71)/2			14.07 (e)	(a − e) = 4.5	Miscible