Hot Melt Extruded Amorphous Solid Dispersion of Posaconazole with Improved Bioavailability: Investigating Drug-Polymer Miscibility with Advanced Characterisation

<table class="table-group" id="tab5"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td align="left">Parameters</td><td align="center">PCZ crystalline</td><td align="center">Noxafil</td><td align="center">PZ1 SD</td><td align="center">PZ4 SD</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td align="left"><svg height="15.6875" id="M113" style="vertical-align:-3.22282pt" version="1.1" viewbox="0 0 35.299999 15.6875" width="35.299999" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> (ng/mL)</td><td align="center">27.42 ± 11.26</td><td align="center">134.74 ± 47.24</td><td align="center">317.97 ± 14.58</td><td align="center">265.36 ± 22.35</td></tr><tr><td align="left"><svg height="15.8375" id="M114" style="vertical-align:-3.22282pt" version="1.1" viewbox="0 0 34.637501 15.8375" width="34.637501" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> (h)</td><td align="center">6 ± 1.22</td><td align="center">5 ± 1.31</td><td align="center">1 ± 1.25</td><td align="center">1 ± 1.37</td></tr><tr><td align="left"><svg height="17.5375" id="M115" style="vertical-align:-4.68874pt" version="1.1" viewbox="0 0 67.175003 17.5375" width="67.175003" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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<g transform="matrix(.012,-0,0,-.012,50.95,15.45)"><path d="M447 623l8 -12l-283 -613l-74 -10l-7 11q174 283 297 551h-216q-48 0 -62.5 -12t-33.5 -63h-29q10 60 18 148h382z" id="x37"></path></g><g transform="matrix(.012,-0,0,-.012,56.661,15.45)"><path d="M412 140l28 -9q0 -2 -35 -131h-373v23q112 112 161 170q59 70 92 127t33 115q0 63 -31 98t-86 35q-75 0 -137 -93l-22 20l57 81q55 59 135 59q69 0 118.5 -46.5t49.5 -122.5q0 -62 -29.5 -114t-102.5 -130l-141 -149h186q42 0 58.5 10.5t38.5 56.5z" id="x32"></path></g><g transform="matrix(.012,-0,0,-.012,62.373,15.45)"><path d="M275 270q0 -296 -211 -440l-19 23q75 62 116.5 174t41.5 243t-42 243t-116 173l19 24q211 -144 211 -440z" id="x29"></path></g>
</svg> (ng h/mL)</td><td align="center">880.35 ± 124.35</td><td align="center">4707.28 ± 245.14</td><td align="center">10159.64 ± 1024.56</td><td align="center">8354.28 ± 786.69</td></tr><tr><td align="left"><svg height="16.2125" id="M116" style="vertical-align:-3.25793pt" version="1.1" viewbox="0 0 22.875 16.2125" width="22.875" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> (h)</td><td align="center">18.24 ± 2.34</td><td align="center">25.58 ± 3.75</td><td align="center">25.12 ± 1.66</td><td align="center">25.87 ± 2.44</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<i>In vivo</i> pharmacokinetic parameters of the PCZ, Noxafil, PZ1, and PZ4 tested.

BioMed Research International

tab5

Table 5

Table 5: Hot Melt Extruded Amorphous Solid Dispersion of Posaconazole with Improved Bioavailability: Investigating Drug-Polymer Miscibility with Advanced Characterisation 

Table 5 | Hot Melt Extruded Amorphous Solid Dispersion of Posaconazole with Improved Bioavailability: Investigating Drug-Polymer Miscibility with Advanced Characterisation 