BioMed Research International / 2014 / Article / Tab 5

Research Article

Hot Melt Extruded Amorphous Solid Dispersion of Posaconazole with Improved Bioavailability: Investigating Drug-Polymer Miscibility with Advanced Characterisation

Table 5

In vivo pharmacokinetic parameters of the PCZ, Noxafil, PZ1, and PZ4 tested.

ParametersPCZ crystallineNoxafilPZ1 SDPZ4 SD

(ng/mL)27.42 ± 11.26134.74 ± 47.24317.97 ± 14.58265.36 ± 22.35
(h)6 ± 1.225 ± 1.311 ± 1.251 ± 1.37
(ng h/mL)880.35 ± 124.354707.28 ± 245.1410159.64 ± 1024.568354.28 ± 786.69
(h)18.24 ± 2.3425.58 ± 3.7525.12 ± 1.6625.87 ± 2.44