Commercial Bovine Proteoglycan Is Highly Arthritogenic and Can Be Used as an Alternative Antigen Source for PGIA Model

Figure 2

Representative clinical scores of hind paws (first column) and forepaws (second column) and histological sections of mice joints (third and fourth columns) with arthritis induced by bovine PG. Female BALB/c retired breeder mice paws were collected 70 days after the disease induction. The rectangles represent the regions highlighted in the fourth column. Head arrows indicate single joint inflammation; lines indicate ankle thickening; filled arrows indicate the synovial membrane. SS: synovial space; C: cartilage; B: bone; I: inflammatory infiltrate; P: pannus; BE: bone erosion.