Association of Single Nucleotide Polymorphisms in Estrogen Receptor Alpha Gene with Susceptibility to Knee Osteoarthritis: A Case-Control Study in a Chinese Han Population

Table 3

Genotype and allele frequencies of rs2234693 and rs9340799 of the ESR1 gene with a stratification by K/L grades.

K/L grading	Number	rs2234693						rs9340799
		Genotype (frequency)			Allele (frequency)		H-WE	Genotype (frequency)			Allele (frequency)		H-WE
		TT	TC	CC	T	C	𝑃 value	AA	AG	GG	A	G	𝑃 value
Grade 2	255	82 (0.321)	120 (0.471)	53 (0.208)	284 (0.557)	226 (0.443)	0.458	156 (0.612)	81 (0.318)	18 (0.070)	393 (0.771)	117 (0.229)	0.105
Grade 3	119	46 (0.387)	54 (0.454)	19 (0.159)	146 (0.613)	92 (0.387)	0.638	74 (0.622)	42 (0.353)	3 (0.025)	190 (0.798)	48 (0.202)	0.295
Grade 4	95	39 (0.410)	43 (0.453)	13 (0.137)	121 (0.637)	69 (0.363)	0.834	57 (0.600)	29 (0.305)	9 (0.095)	143 (0.753)	47 (0.247)	0.079

K/L: Kellgren-Lawrence; No.: number; H-WE: Hardy-Weinberg Equilibrium.