Association of Single Nucleotide Polymorphisms in Estrogen Receptor Alpha Gene with Susceptibility to Knee Osteoarthritis: A Case-Control Study in a Chinese Han Population

Table 4

Association of the rs2234693 with knee OA in the Chinese Han population with a stratification by gender.

Groups compared	TT versus TC + CC			TT + TC versus CC			T allele versus C allele			All genotyped*
	OR	95% CI	𝑃 value	OR	95% CI	𝑃 value	OR	95% CI	𝑃 value	𝑃 value
All patients (𝑛=469) versus all controls (𝑛=514)	1.133	0.874–1.469	0.345	1.316	0.937–1.850	0.113	1.149	0.959–1.377	0.133	0.259
Female patients (𝑛=356) and female controls (𝑛=120)	1.282	0.836–1.967	0.254	2.087	1.086–4.009	0.025	1.359	1.003–1.840	0.047	0.073
Male patients (𝑛=113) and male controls (394)	0.917	0.599–1.405	0.690	0.954	0.538–1.691	0.871	0.943	0.693–1.283	0.709	0.923

OR: Odds Ratio; CI: confidence interval.
∗TT, TC, and CC genotypes were grouped together and a 2×3 contingency-table analysis was performed.