GCK Gene-Body Hypomethylation Is Associated with the Risk of Coronary Heart Disease

Table 1

Comparison of GCK gene DNA methylation levels within subgroups and gender separately.

DNA methylation (%)	Case	Control	Subgroup P	Male	Female	Gender P	Gender * subgroup Interaction P
CpG1	50.00 ± 8.34	52.72 ± 8.25	0.232	52.11 ± 8.01	50.61 ± 8.73	0.955	0.556
CpG2	43.42 ± 7.93	49.42 ± 8.26	0.005*	46.14 ± 9.16	46.69 ± 8.10	0.932	0.668
CpG3	56.81 ± 8.74	62.06 ± 9.58	0.036*	59.92 ± 9.04	58.94 ± 10.00	0.887	0.909
CpG4	48.86 ± 7.44	53.67 ± 7.11	0.031*	50.83 ± 7.48	51.69 ± 7.83	0.258	0.667
Mean	49.77 ± 6.43	54.47 ± 7.65	0.018*	52.25 ± 7.23	51.99 ± 7.67	0.842	0.658

The P values were adjusted by age, history of smoking, diabetes, and hypertension.
* P < 0.05.