GCK Gene-Body Hypomethylation Is Associated with the Risk of Coronary Heart Disease

Table 2

Comparison of GCK gene DNA methylation levels between cases and controls in male and female separately.

DNA methylation (%)	Male			Female
	Case	Control	P	Case	Control	P
CpG1	50.17 ± 8.50	54.06 ± 7.19	0.321	49.83 ± 8.42	51.39 ± 9.20	0.674
CpG2	42.72 ± 9.52	49.56 ± 7.57	0.030*	44.11 ± 6.15	49.28 ± 9.12	0.067
CpG3	57.17 ± 8.99	62.67 ± 8.46	0.155	56.44 ± 8.73	61.44 ± 10.79	0.138
CpG4	48.06 ± 7.01	53.61 ± 7.06	0.085	49.67 ± 7.96	53.72 ± 7.36	0.228
Mean	49.53 ± 6.58	54.97 ± 6.98	0.063	50.01 ± 6.45	53.96 ± 8.44	0.168

The P values were adjusted by age, history of smoking, diabetes, and hypertension.
* P < 0.05.