Jacobsen Catalyst as a Cytochrome P450 Biomimetic Model for the Metabolism of Monensin A

Table 2

Values of the effect caused by monensin A and its products (1 μM) on respiratory parameters.

	V3	V4	RCR	ADP/O
Control	66.107 ± 2.45^a	9.798 ± 0.32^a	6.747 ± 0.12^a	2.874 ± 0.03^a
Monensin A	64.097 ± 2.35^a	14.12 ± 0.97^b	4.548 ± 0.16^b	1.498 ± 0.01^b
Metabolite 1	66.363 ± 2.29^a	10.02 ± 0.11^a	6.623 ± 0.27^a	2.757 ± 0.09^a
Metabolite 2	66.730 ± 1.95^a	9.832 ± 0.07^a	6.786 ± 0.15^a	2.728 ± 0.06^a

∗Respiration rates in nmol O₂/mg protein/min were performed in mitochondria isolated from rat liver (1.0 mg protein·mL⁻¹) incubated.
∗Different letters represent significant differences between treatments according to Tukey’s test (𝑃<0,05).
∗V3 = state 3; V4 = state 4; RCR = respiratory control ratio; ADP/O = phosphorylation efficiency.