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BioMed Research International
Volume 2014, Article ID 154594, 8 pages
Research Article

An Unsupervised Approach to Predict Functional Relations between Genes Based on Expression Data

Computational Systems Biology Lab, Nara Institute of Science and Technology, Ikoma, Nara 630-0192, Japan

Received 1 November 2013; Revised 31 January 2014; Accepted 3 February 2014; Published 31 March 2014

Academic Editor: Farit Mochamad Afendi

Copyright © 2014 Md. Altaf-Ul-Amin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Table 1: The tool PRIMA (PRomoter Integration in Microarray Analysis) from the software package EXPANDER was used to verify the presence of similar binding sites in the promoters of the genes included in individual modules. Total 180 modules were found to have p-values less than 10-3 in the context of binding site enrichment of 57 various transcription factors. One module may be associated to more than one transcription factor. Supplementary Table 1 is the enrichment table generated by Expander.

  1. Supplementary Material