Formulation and Optimization of Polymeric Nanoparticles for Intranasal Delivery of Lorazepam Using Box-Behnken Design: <i>In Vitro</i> and <i>In Vivo</i> Evaluation

<table>3D response surface plots showing effect of PLGA (<i>X </i><sub>1</sub>) and poloxamer (<i>X </i><sub>2</sub>) on % drug entrapment.</table>

BioMed Research International

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Figure 4: Formulation and Optimization of Polymeric Nanoparticles for Intranasal Delivery of Lorazepam Using Box-Behnken Design: <i>In Vitro</i> and <i>In Vivo</i> Evaluation 

Figure 4 | Formulation and Optimization of Polymeric Nanoparticles for Intranasal Delivery of Lorazepam Using Box-Behnken Design: In Vitro and In Vivo Evaluation 