Table 2: Effect of independent process variables on dependent variable.

FormulationPLGA mg/mLPoloxamer mg/mLw/o phase volume ratioDrug conc. Mg/mL -Average d·nm
(±SD)
% Drug entrapment
(±SD)
PDI
(±SD)

1.35261211 ± 0.1170 ± 1.30.183 ± 0.002
2.35265220 ± 0.888.48 ± 0.80.150 ± 0.003
3.108.50103176 ± 0.583 ± 0.50.048 ± 0.001
4.358.5021177 ± 1.271 ± 1.50.17 ± 0.004
5.10263205 ± 0.981 ± 0.70.315 ± 0.003
6.108.5065177 ± 1.683.5 ± 0.50.110 ± 0.002
7.108.5023184 ± 1.575 ± 0.350.078 ± 0.002
8.358.5063197 ± 0.586.6 ± 0.650.112 ± 0.004
9.608.5061271 ± 0.876 ± 0.220.24 ± 0.001
10.351565192 ± 1.484.3 ± 0.350.19 ± 0.001
11.101563177 ± 0.680 ± 2.10.04 ± 0.003
12.60263 318 ± 1.290.1 ± 0.80.441 ± 0.002
13.3515103191 ± 1.583.5 ± 10.17 ± 0.003
14.601563228 ± 0.582 ± 0.40.15 ± 0.001
15.608.5023241 ± 0.488 ± 0.850.309 ± 0.005
16.351561182.5 ± 0.566.4 ± 0.20.09 ± 0.002
17.35223215 ± 0.787.83 ± 0.10.15 ± 0.005
18.608.5065261 ± 0.589 ± 1.70.20 ± 0.001
19.358.5025193 ± 1.188 ± 1.50.10 ± 0.002
20.108.5061167 ± 0.865.5 ± 1.10.21 ± 0.005
21.358.50101192 ± 1.769 ± 0.60.28 ± 0.001
22.352103241 ± 1.588 ± 1.50.21 ± 0.003
23.358.50105202 ± 1.287 ± 10.19 ± 0.002
24.351523186 ± 1.584 ± 0.80.15 ± 0.002
25.608.50103283 ± 0.788 ± 1.40.15 ± 0.006
26.358.5063193 ± 0.585.12 ± 0.70.102 ± 0.004