Osthole Attenuates Doxorubicin-Induced Apoptosis in PC12 Cells through Inhibition of Mitochondrial Dysfunction and ROS Production

Figure 4

Effect of osthole on DOX-induced mitochondrial membrane potential (MMP) collapse. Cells were pretreated with osthole (7 μg/cc) 2 h before exposure to 5 μM of DOX. Graphs showing the change in MMP as represented by the mean fluorescence intensity (MFI) of rhodamine 123. ^###𝑃<0.001 versus control group. ^∗∗𝑃<0.01 versus group treated with DOX alone.